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Metabolic Research

NAD+ (1000 mg Vial)

Nicotinamide adenine dinucleotide (NAD+) is an essential redox coenzyme and sirtuin cofactor involved in cellular energy metabolism, DNA repair, and mitochondrial function. Research protocols explore NAD+ repletion for aging-related decline and metabolic dysfunction.

Vial

1000 mg vial (lyophilized NAD+)

Category

Metabolic Research

Research highlights

A substrate for PARP and sirtuin enzymes governing DNA repair and epigenetic regulation.
Research examines restoration of mitochondrial NAD+ pools depleted by age and stress.
Often studied alongside NAD+ precursors such as NMN and NR.

How this works

NAD+ functions as a hydride-transfer coenzyme in redox reactions (NAD+/NADH) and as a substrate for sirtuins, PARPs, and CD38, regulating mitochondrial biogenesis, oxidative stress responses, and DNA repair. Research examines whether restoring intracellular NAD+ concentrations that decline with age supports sirtuin-mediated pathways and metabolic homeostasis.

Storage

  • Lyophilized: store at −20 °C (−4 °F) in dry, dark conditions; short-term at 2–8 °C acceptable.
  • Reconstituted: refrigerate at 2–8 °C (35.6–46.4 °F); use within 14–28 days; protect from light.
  • Avoid repeated freeze–thaw cycles of reconstituted solution.

Research-use notice

⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.

Peer-Reviewed References

Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.

  1. 1
    Johnson S, Imai SI. NAD+ biosynthesis, aging, and disease. Metabolism. 2018. doi:10.1016/j.metabol.2018.08.001.View source
  2. 2
    Verdin E. NAD+ in aging, metabolism, and hormone regulation. Nat Rev Endocrinol. 2015. doi:10.1038/nrendo.2015.117.View source
  3. 3
    Elhassan YS, et al. Nicotinamide mononucleotide (NMN) and NAD+ metabolism in human health and disease. Trends Endocrinol Metab. 2017. doi:10.1016/j.tem.2017.11.001.View source