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Neuroendocrine Research

Kisspeptin (10 mg Vial)

Kisspeptin-54 is a 54-amino-acid peptide cleaved from the kisspeptin-145 precursor and the endogenous ligand of the GPR54 (KISS1R) receptor. Studied for its role as a master regulator of gonadotropin-releasing hormone (GnRH) pulsatility, reproductive axis signaling, and hypothalamic-pituitary-gonadal (HPG) axis function.

Vial

10 mg vial (lyophilized kisspeptin-54)

Category

Neuroendocrine Research

Research highlights

Stimulates GnRH neuron firing and downstream LH/FSH pulsatility in research models.
Explored in research on hypogonadotropic hypogonadism and reproductive-axis signaling.
Loss-of-function KISS1R mutations are associated with absent puberty.

How this works

Kisspeptin binds the KISS1R (GPR54) G-protein-coupled receptor on hypothalamic GnRH neurons, triggering phospholipase C / IP3 signaling and intracellular calcium release that drives GnRH pulse generation. GnRH pulses in turn regulate anterior pituitary LH and FSH secretion, governing gonadal steroidogenesis and gametogenesis. Loss-of-function mutations in KISS1R are associated with hypogonadotropic hypogonadism and absent puberty, establishing kisspeptin as an upstream gatekeeper of reproductive axis activation.

Storage

  • Lyophilized: store at −20 °C (−4 °F) in dry, dark conditions; short-term at 2–8 °C acceptable.
  • Reconstituted: refrigerate at 2–8 °C (35.6–46.4 °F); use within 14–28 days; avoid freeze–thaw.
  • Allow vials to reach room temperature before opening to reduce condensation.

Research-use notice

⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.

Peer-Reviewed References

Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.

  1. 1
    d'Anglemont de Tassigny X, et al. Kisspeptin: a gatekeeper of reproduction. Nat Rev Endocrinol. 2012. doi:10.1038/nrendo.2012.106.View source
  2. 2
    Decourt C, et al. Gonadotrophin-releasing hormone (GnRH) expression and kisspeptin signaling in the control of reproduction. Mol Cell Endocrinol. 2013. doi:10.1016/j.mce.2013.07.010.View source
  3. 3
    George JT, et al. Kisspeptin-54 is a key mediator of sexual behavior in men: a pilot study. J Clin Endocrinol Metab. 2013. doi:10.1210/jc.2013-1381.View source