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Longevity / Geroprotective

Epitalon (10 mg Vial)

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from pineal gland research. Studied for telomerase activation, telomere elongation, melatonin normalization, and geroprotective effects.

Vial

10 mg vial

Category

Longevity / Geroprotective

Research highlights

Activates telomerase to promote telomere elongation in cell cultures.
Stimulates nocturnal melatonin release from the pineal gland.
Human trials showed improved cardiovascular outcomes over 12-year follow-up.

How this works

Epitalon's primary mechanism involves telomerase activation, promoting telomere elongation in cells. In vitro studies demonstrated it induced telomerase and lengthened telomeres in human cell cultures. It also influences the neuroendocrine system by stimulating nocturnal melatonin release from the pineal gland, normalizing circadian hormone rhythms in aged subjects. Additional reported effects include antioxidant activity and immune modulation.

Storage

  • Lyophilized: store at −20 °C (−4 °F) for long-term; refrigerate at 2–8 °C for routine use.
  • Reconstituted: refrigerate at 2–8 °C; use within 2–4 weeks; avoid freeze–thaw.
  • Reconstitute one vial at a time (every 2 days) to keep solutions fresh.

Research-use notice

⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.

Peer-Reviewed References

Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.

  1. 1
    Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003. doi:10.1023/a:1025493705728.View source
  2. 2
    Anisimov VN, et al. Effect of Epitalon on the lifespan of elderly and senile rats. Mech Ageing Dev. 2004. doi:10.1016/j.mad.2004.03.007.View source
  3. 3
    Khavinson V, et al. Effect of Epithalon on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People. Neuro Endocrinol Lett. 2001.View source