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GH Secretagogue

CJC-1295 No DAC (5 mg Vial)

Synthetic 29-amino-acid GHRH analog (Modified GRF 1–29) studied for pulsatile growth hormone secretion while preserving the body's physiologic feedback loop.

Vial

5 mg vial

Category

GH Secretagogue

Research highlights

A short half-life produces discrete GH pulses in research models.
Preserves the physiologic GH feedback loop, unlike exogenous GH administration.
Studied as a GHRH analog for pulsatile growth-hormone secretion.

How this works

CJC-1295 No DAC has four amino acid substitutions that enhance stability against enzymatic degradation. It binds to GHRH receptors on pituitary somatotrophs, stimulating synthesis and pulsatile release of endogenous growth hormone. Unlike exogenous GH, GHRH analogs preserve the physiologic feedback loop, resulting in more natural GH pulsatility without supraphysiological GH levels.

Storage

  • Lyophilized: store at 2–8 °C; for extended storage, freeze at ≤−20 °C.
  • Reconstituted: refrigerate at 2–8 °C; use within 1–2 weeks; avoid freeze–thaw.
  • Allow vials to reach room temperature before opening.

Research-use notice

⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.

Peer-Reviewed References

Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.

  1. 1
    Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006. doi:10.1210/jc.2005-1258.View source
  2. 2
    Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295. J Clin Endocrinol Metab. 2006. doi:10.1210/jc.2005-1995.View source