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Metabolic Research

NAD+ (500 IU Vial)

Nicotinamide adenine dinucleotide (NAD+) is an endogenous coenzyme found in all living cells. Studied extensively for roles in mitochondrial energy metabolism, DNA repair, sirtuin activation, and cellular aging processes.

Vial

500 IU (500 mg) vial

Category

Metabolic Research

Research highlights

An endogenous coenzyme involved in cellular energy metabolism and DNA repair.
Serves as a substrate for PARP enzymes and sirtuins.
Studied in the context of age-related decline in cellular NAD+ levels.

How this works

NAD+ is a critical cofactor in cellular redox reactions and oxidative phosphorylation. It serves as a substrate for PARP enzymes (DNA repair), sirtuins (epigenetic regulation and metabolic adaptation), and CD38 (calcium signaling). Research links NAD+ repletion to improved mitochondrial function, reduced oxidative stress markers, and modulation of inflammatory pathways.

Storage

  • Lyophilized: store at 2–8 °C (refrigerator) or −20 °C (freezer) in dry, dark conditions.
  • Reconstituted: refrigerate at 2–8 °C; use within 14 days; avoid freeze–thaw cycles.
  • NAD+ is sensitive to light and oxidation — keep vials sealed and protected.

Research-use notice

⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.

Peer-Reviewed References

Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.

  1. 1
    Yoshino J, et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018. doi:10.1016/j.cmet.2017.11.002.View source
  2. 2
    Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018. doi:10.1016/j.cmet.2018.02.011.View source
  3. 3
    Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. doi:10.1038/s41467-018-03421-7.View source