How this works
MOTS-C is researched as a mitochondrial stress signal that activates AMPK-related pathways, influencing glucose uptake, fatty-acid oxidation, mitochondrial respiration, and cellular stress-response signaling.
Back to library
Mitochondrial Peptide
MOTS-C
Mitochondrial-derived peptide studied for AMPK activation, metabolic signaling, insulin sensitivity, and exercise-capacity research.
Vial
10 mg vial
Category
Mitochondrial Peptide
Research highlights
A mitochondrial-derived peptide studied for AMPK-related metabolic signaling.
Research examines glucose uptake, fatty-acid oxidation, and mitochondrial respiration.
No completed human clinical trials are reflected in the source literature.
Storage
- Lyophilized: store frozen, dry, and dark.
- Reconstituted: refrigerate at 2–8 °C and use within 7 days for best potency.
- Aliquoting may help avoid repeated freeze–thaw cycles.
Research-use notice
⚠️ All peptides on this site are not FDA approved and are not approved for human use outside of a clinical trial. f4Labs presents this material as a research reference only — not medical advice, diagnosis, or treatment guidance.
Peer-Reviewed References
Mechanism descriptions and research context are informed by the following published literature. Click any citation to view the source.
- 1Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. doi:10.1016/j.cmet.2015.02.009.View source
- 2Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021. doi:10.1038/s41467-021-26459-2.View source
- 3Kim SJ, et al. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017. doi:10.1113/JP272472.View source